Mean effect across BMI strata of allelic substitutions at representative variants displaying genome-wide significant association with SU in at least one BMI stratum and displaying nominally significant difference in effect size across BMI strata.

<p>Effect size is on standardised age-adjusted SU levels. Error bars indicate the standard errors of the mean effect estimates within a BMI category. Horizontal lines indicate nominally significant (p &lt; 0.05) differences in mean effect sizes between BMI categories, ** indicates significance at the 1% level taking into account the multiple comparisons performed. Differences in mean effect sizes between BMI strata were tested pairwise using the classical z-test, and P_diff denotes the 2-sided test corresponding P-value. Lean: BMI &lt; 25 kg/m², overweight: 25 ≤ BMI ≤ 30 kg/m², obese: BMI &gt; 30 kg/m².</p

Most significant BMI x SNP interaction terms for urate GWAMA.

<p>A1, allele for which effect (β) is reported; A2 alternate allele, fqA1 weighted average effect-allele frequency across studies meta-analyzed; s.e. standard error of the effect estimate, I² meta-analysis heterogeneity statistic. The interaction term is modelled within a linear model where standardised SU levels (after adjustment for age and sex) is regressed on BMI, SNP and their interaction. βinter is the regression coefficient for the interaction term.</p><p>Most significant BMI x SNP interaction terms for urate GWAMA.</p

Forest plots of effect sizes within BMI stratum for variants with the two most significant mean effect size differences between BMI stratum.

<p>A. <i>RBMS1</i>-<i>TANK</i> locus and B. <i>TSPYL5</i> locus. The overall inverse—variance-weighted mean effect per BMI stratum is calculated assuming fixed effect across studies and represented by a lozenge, associated P-value displayed as P. Measure of heterogeneity between studies is reported (I-squared) with associated P-value for significance (p). P_diff is the test of difference in mean-effect size P-value. For study abbreviations and references, see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0119752#pone.0119752.s005" target="_blank">S1 Table</a>.</p